RESUMO
Two new ursane-type triterpene glucosides, 2alpha,3alpha,24-trihydroxyurs-12,18-dien-28-oic acid beta-D-glucopyranosyl ester (1) and 2alpha,3alpha,23-trihydroxyurs-12,19(29)-dien-28-oic acid beta-D-glucopyranosyl ester (2), were isolated from the roots of Rosa laevigata, together with three known compounds: 2alpha,3beta,19alpha-trihydroxyurs-12-en-28-oic acid beta-Dglucopyranosyl ester (3), 2alpha,3alpha,19alpha-trihydroxyurs-12-en-28-oic acid beta-D-glucopyranosyl ester (4) and 2alpha,3beta,19alpha,23-tetrahydroxyurs-12-en-28-oic acid beta-D-glucopyranosyl ester (5). The structures of new compounds were established on the basis of detailed 1D and 2D NMR spectroscopic analyses. Compounds 2 and 5 exhibited modest in vitro antifungal activities against Candida albicans and C. krusei.
Assuntos
Glucosídeos/química , Raízes de Plantas/química , Rosa/química , Triterpenos/química , Antifúngicos/química , Antifúngicos/isolamento & purificação , Antifúngicos/farmacologia , Candida/efeitos dos fármacos , Candida albicans/efeitos dos fármacos , Glucosídeos/isolamento & purificação , Glucosídeos/farmacologia , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Estrutura Molecular , Triterpenos/isolamento & purificação , Triterpenos/farmacologiaRESUMO
Twelve dihydrostilbenes, stilbostemins N-Y (1-12), and a phenanthraquinone, stemanthraquinone (13), were isolated and identified from roots of Stemona tuberosa, along with five known dihydrostilbenes. Their structures were established on the basis of 1D and 2D NMR and other spectroscopic analyses. Dihydrostilbene 8 exhibited strong activity against Bacillus pumilus (MIT 12.5-25 microg/mL). Many tested compounds exhibited moderate antibacterial activities.
Assuntos
Antibacterianos/química , Antibacterianos/farmacologia , Raízes de Plantas/química , Stemonaceae/química , Estilbenos/química , Estilbenos/farmacologia , Bacillus/efeitos dos fármacos , Espectroscopia de Ressonância Magnética , Estrutura MolecularRESUMO
Three new dimeric sesquiterpenoids, chloramultilides B-D ( 1- 3), along with 10 known sesquiterpenoids, were isolated from the whole plant of Chloranthus spicatus. Their structures were established by physical data (1D and 2D NMR, MS). The structure and absolute configuration of 1 was confirmed by X-ray crystallography. Compound 1 exhibited moderate in vitro antifungal activity.
